ABSTRACT
Although previous studies have indicated a generally positive association between social media use and general trust, the differential impacts of traditional media and social media on general trust and their underlying mechanisms have yet to be fully elaborated. Drawing on the three-dimensional definition of social capital (i.e., personal networks, social norms, and interpersonal trust) as its theoretical framework, this study comparatively examines the impacts of traditional media and social media on general trust, focusing on the mediating role of social capital. Analyses of survey data from China (N = 1,519) during the first stage of COVID-19 demonstrate that social media has a positive relationship with general trust. In addition, social media has two opposing indirect effects on general trust through increased interpersonal trust and personal networks. In contrast, traditional media use has no positive relationship with general trust, either directly or indirectly, although it has a positive relationship with social norms. The differential consequences of using traditional media and social media on general trust are discussed from the perspective of social capital.
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic underlines a persistent threat of respiratory tract infectious diseases and warrants preparedness for a rapid response. At present, COVID-19 has had a serious social impact and imposed a heavy global burden on public health. The exact pathogenesis of COVID-19 has not been fully elucidated. Since the outbreak of COVID-19, a renewed attention has been brought to Toll-like receptors (TLRs). Available data and new findings have demonstrated that the interaction of human TLRs and SARS-CoV-2 is a vital mediator of COVID-19 immunopathogenesis. TLRs such as TLR2, 4, 7 and 8 are potentially important in viral combat and activation of immunity in patients with COVID-19. Therapeutics targeting TLRs are currently considered promising options against the pandemic. A number of TLR-targeting immunotherapeutics are now being investigated in preclinical studies and different phases of clinical trials. In addition, innovative vaccines based on TLRs under development could be a promising approach for building a new generation of vaccines to solve the current challenges. In this review, we summarize recent progress in the role of TLRs in COVID-19, focusing the new candidate drugs targeting TLRs, the current technology and potential paths forward for employing TLR agonists as vaccine adjuvants.Copyright © 2023 The Scandinavian Foundation for Immunology.
ABSTRACT
Objective To analyze the research status and development trend of evidence-based social sciences, and to explore the synergistic relationship among branches of various fields. Methods A comprehensive search for research related to evidence-based social sciences published between the establishment of the database and September 2022 was conducted on the Web of Science, China Science Citation Database (CSCD), and Chinese Social Sciences Citation Index (CSSCI). The VOSviewer software was used to analyze the author and keywords and to perform the visualization. Results A total of 6 969 papers were included, 195 of which were in Chinese. The first paper, published in 1995, was on evidence-based management. The number of papers published on evidence-based social science research presented a trend of increasing continuously. The country with the most papers published was the United States;the institution outside China with the most papers published was McMaster University;and the institution in China with the most papers published was Sichuan University. The analysis of keywords showed that evidence-based policy, evidence-based practice, evidence-based management, and evidence-based decision-making appeared more frequently;research questions focused on evidence-based health policy development, application of big data in the context of COVID-19, evidence of climate change-induced disease, and real world research. Conclusion All the fields of evidence-based social sciences are closely related to each other in terms of research content and methods, and it presents a multi-level and multi-field crossover with evidence-based medicine. However, evidence-based social sciences in China are still in their infancy. Therefore, it is necessary to improve the methodological system of evidence-based social sciences, enrich the research content of social sciences, speed up the filling of evidence gaps in various fields, and promote the improvement and sustainable development of evidence-based social sciences.Copyright © 2023 West China University of Medical Science. All rights reserved.
ABSTRACT
In recent years, the epidemic model with anomalous diffusion has gained popularity in the literature. However, when introducing anomalous diffusion into epidemic models, they frequently lack physical explanation, in contrast to the traditional reaction-diffusion epidemic models. The point of this paper is to guarantee that anomalous diffusion systems on infectious disease spreading remain physically reasonable. Specifically, based on the continuous-time random walk (CTRW), starting from two stochastic processes of the waiting time and the step length, time-fractional space-fractional diffusion, time-fractional reaction-diffusion and fractional-order diffusion can all be naturally introduced into the SIR (S: susceptible, I: infectious and R: recovered) epidemic models, respectively. The three models mentioned above can also be applied to create SIR epidemic models with generalized distributed time delays. Distributed time delay systems can also be reduced to existing models, such as the standard SIR model, the fractional infectivity model and others, within the proper bounds. Meanwhile, as an application of the above stochastic modeling method, the physical meaning of anomalous diffusion is also considered by taking the SEIR (E: exposed) epidemic model as an example. Similar methods can be used to build other types of epidemic models, including SIVRS (V: vaccine), SIQRS (Q: quarantined) and others. Finally, this paper describes the transmission of infectious disease in space using the real data of COVID-19. © 2023 World Scientific Publishing Company.
ABSTRACT
Background Taletrectinib is a potent, next-generation, CNS-active, ROS1 tyrosine kinase inhibitor (TKI) with selectivity over TRKB. In previous reports from TRUST-I, taletrectinib showed meaningful clinical efficacy and was well tolerated in pts with ROS1+ NSCLC (n = 109) regardless of crizotinib (CRZ) pretreatment status. We report updated efficacy and safety data with ~1.5 yr follow-up. Methods TRUST-I is a multicenter, open-label, single-arm study with two cohorts: ROS1 TKI-naive and CRZ-pretreated. Pts in both cohorts received taletrectinib 600 mg QD. Key study endpoints included IRC-confirmed ORR (cORR), DoR, disease control rate (DCR), PFS, and safety. A pooled analysis of ORR, PFS, and safety including pts from additional clinical trials was also conducted. Results In the 109 pts from TRUST-I (enrolled prior to Feb 2022) the median follow-up was 18.0 mo in TKI-naive (n = 67) and 16.9 mo in CRZ-pretreated pts (n = 42). cORR was 92.5% in TKI-naive and 52.6% in CRZ-pretreated pts (table). Median DoR (mDoR) and mPFS were not reached. Intracranial-ORR was 91.6%;ORR in pts with G2032R was 80.0%. In a pooled analysis with phase I studies, ORR was 89.5% and 50.0% for TKI-naive and CRZ-pretreated pts, respectively;mPFS was 33.2 mo and 9.8 mo. In 178 pts treated at 600 mg QD, treatment-emergent adverse events (TEAEs) were 92.7%;most (64.0%) were grade 1-2. The most common TEAEs were increased AST (60.7%), increased ALT (55.6%), and diarrhea (55.6%). Neurological TEAEs (dizziness, 18.5%;dysgeusia, 12.4%) and discontinuations due to TEAEs (3.4%) were low. Further updated results will be presented. [Formula presented] Conclusions With additional follow-up, taletrectinib continued to demonstrate meaningful efficacy outcomes including high response rates, prolonged PFS, robust intracranial activity, activity against G2032R, and tolerable safety with low incidence of neurological AEs. Clinical trial identification NCT04395677. Editorial acknowledgement Medical writing and editorial assistance were provided by Arpita Kulshrestha of Peloton Advantage, LLC, an OPEN Health company, and funded by AnHeart Therapeutics, Inc Legal entity responsible for the study AnHeart Therapeutics, Inc. Funding AnHeart Therapeutics, Inc. Disclosure S. He: Financial Interests, Personal, Other, Employment: AnHeart Therapeutics. T. Seto: Financial Interests, Institutional, Research Grant: AbbVie, Chugai Pharmaceutical, Daiichi Sankyo, Eli Lilly Japan, Kissei Pharmaceutical, MSD, Novartis Pharma, Pfizer Japan, Takeda Pharmaceutical;Financial Interests, Personal, Other, Employment: Precision Medicine Asia;Financial Interests, Personal, Speaker's Bureau, Honoraria for lectures: AstraZeneca, Bristol-Myers Squibb, Chugai Pharmaceutical, Covidien Japan, Daiichi Sankyo, Eli Lilly Japan, Kyowa Hakko Kirin, MSD, Mochida Pharmaceutical, Nippon Boehringer Ingelheim, Novartis Pharma, Ono Pharmaceutical, Pfizer Japan, Taiho Pharmaceutical, Takeda Pharmaceutical, Towa Pharmaceutical. C. Zhou: Financial Interests, Personal, Other, Consulting fees: Innovent Biologics Qilu, Hengrui, TopAlliance Biosciences Inc;Financial Interests, Personal, Speaker's Bureau, Payment or honoraria: Eli Lilly China, Sanofi, BI, Roche, MSD, Qilu, Hengrui, Innovent Biologics, C-Stone LUYE Pharma, TopAlliance Biosciences Inc, Amoy Diagnositics, AnHeart. All other authors have declared no conflicts of interest.Copyright © 2023 International Association for the Study of Lung Cancer. Published by Elsevier Inc.
ABSTRACT
COVID-19 has been rampant across the globe since it was discovered in 2020, but the method of virus detection still lacks efficiency and requires human resources. Given the slow delivery of the PCR test and the many possible false negatives of the rapid tests, medical imaging such as a chest computed tomography (CT) scan or chest X-ray (CXR) is an alternative and efficient way to detect the coronavirus accurately. For the past two years, many researchers have proposed different deep learning methods for COVID-19 detection using CT scans or CXR images. Due to the lack of available data, our study aims to propose a new deep learning framework VGG-FusionNet that takes advantage of integrating features from both CT scan and CXR images while avoiding some pitfalls from previous studies, including a high risk of bias due to lack of demographic information for the dataset, poor reproducibility, and no evaluation on different data sources to study the generalizability. Specifically, we use the convolutional layers of GoogLeNet, ResNet, and VGG to extract features from CT scan and CXR images and fuse them before training through fully connected layers. The result shows that using VGG's convolutional layers achieves the best overall performance with an accuracy of 0.93. Our proposed framework outperforms the deep learning models, using features from CT scans or CXR. © 2022 IEEE.
ABSTRACT
Objective To analyze the research status and development trend of evidence-based social sciences, and to explore the synergistic relationship among branches of various fields. Methods A comprehensive search for research related to evidence-based social sciences published between the establishment of the database and September 2022 was conducted on the Web of Science, China Science Citation Database (CSCD), and Chinese Social Sciences Citation Index (CSSCI). The VOSviewer software was used to analyze the author and keywords and to perform the visualization. Results A total of 6 969 papers were included, 195 of which were in Chinese. The first paper, published in 1995, was on evidence-based management. The number of papers published on evidence-based social science research presented a trend of increasing continuously. The country with the most papers published was the United States;the institution outside China with the most papers published was McMaster University;and the institution in China with the most papers published was Sichuan University. The analysis of keywords showed that evidence-based policy, evidence-based practice, evidence-based management, and evidence-based decision-making appeared more frequently;research questions focused on evidence-based health policy development, application of big data in the context of COVID-19, evidence of climate change-induced disease, and real world research. Conclusion All the fields of evidence-based social sciences are closely related to each other in terms of research content and methods, and it presents a multi-level and multi-field crossover with evidence-based medicine. However, evidence-based social sciences in China are still in their infancy. Therefore, it is necessary to improve the methodological system of evidence-based social sciences, enrich the research content of social sciences, speed up the filling of evidence gaps in various fields, and promote the improvement and sustainable development of evidence-based social sciences.Copyright © 2023 West China University of Medical Science. All rights reserved.
ABSTRACT
Objective To analyze the research status and development trend of evidence-based social sciences, and to explore the synergistic relationship among branches of various fields. Methods A comprehensive search for research related to evidence-based social sciences published between the establishment of the database and September 2022 was conducted on the Web of Science, China Science Citation Database (CSCD), and Chinese Social Sciences Citation Index (CSSCI). The VOSviewer software was used to analyze the author and keywords and to perform the visualization. Results A total of 6 969 papers were included, 195 of which were in Chinese. The first paper, published in 1995, was on evidence-based management. The number of papers published on evidence-based social science research presented a trend of increasing continuously. The country with the most papers published was the United States;the institution outside China with the most papers published was McMaster University;and the institution in China with the most papers published was Sichuan University. The analysis of keywords showed that evidence-based policy, evidence-based practice, evidence-based management, and evidence-based decision-making appeared more frequently;research questions focused on evidence-based health policy development, application of big data in the context of COVID-19, evidence of climate change-induced disease, and real world research. Conclusion All the fields of evidence-based social sciences are closely related to each other in terms of research content and methods, and it presents a multi-level and multi-field crossover with evidence-based medicine. However, evidence-based social sciences in China are still in their infancy. Therefore, it is necessary to improve the methodological system of evidence-based social sciences, enrich the research content of social sciences, speed up the filling of evidence gaps in various fields, and promote the improvement and sustainable development of evidence-based social sciences. © 2023 West China University of Medical Science. All rights reserved.
ABSTRACT
The COVID-19 pandemic has resulted in an alarming accumulation of plastic waste. Herein, an integrated hydropyrolysis and hydrocracking process was performed to upcycle disposable masks into fuel-range iso-alkanes over carbon supported ruthenium (Ru/C). Experimental results indicated that catalyst type significantly affected product distribution during the hydropyrolysis and vapor-phase hydrocracking of disposable masks. Compared with zeolites-induced catalytic cascade process where up to ∼25.9 wt% yield of aromatic hydrocarbons such as toluene and xylenes were generated, a ∼82.7 wt% yield of desirable iso-alkanes with a high C5–C12 gasoline selectivity of 95.5% was obtained over Ru/C under 550 °C hydropyrolysis temperature and 300 °C hydrocracking temperature at 0.2 MPa H2. The cascade hydropyrolysis and hydrocracking process also exhibited high adaptability and flexibility in upcycling single-use syringes, food packaging, and plastic bags, generating 79.1, 81.6, and 80.3 wt% yields of fuel range iso/n-alkanes, respectively. This catalytic cascade hydrotreating process provides an efficient and effective approach to convert pandemic-derived plastic waste into gasoline-range fuel products. © 2022 Elsevier Ltd
ABSTRACT
Purpose: This paper aims to use a quantitative approach to explore the role of online learning behavior in students' academic performance during the COVID-19 pandemic. Specifically, the authors probe its mediating effect in the relationship between student motivation (extrinsic and intrinsic) and academic performance in a blended learning context. Design/methodology/approach: Survey data were collected from 148 students taking an organizational behavior course at one Chinese university. The data were paired and analyzed through regression analysis. Findings: The results show that students should actively engage in online learning behavior to maximize the effects of blended learning. Extrinsic motivation was found to positively influence academic performance both directly and indirectly through online learning behavior, while intrinsic motivation affected academic performance only indirectly. Originality/value: Through paired data on extrinsic and intrinsic motivation, online learning behavior and academic performance, this study provides a more nuanced understanding of how online learning behavior affects the focal relationship, and it advances research on the mechanisms underlying the focal relationship. Practitioners should enhance students' online learning behavior to boost blended learning effects during the COVID-19 pandemic. © 2022, Emerald Publishing Limited.
ABSTRACT
When public health emergencies occur, a large amount of low-credibility information is widely disseminated by social bots, and public sentiment is easily manipulated by social bots, which may pose a potential threat to the public opinion ecology of social media. Therefore, exploring how social bots affect the mechanism of information diffusion in social networks is a key strategy for network governance. This study combines machine learning methods and causal regression methods to explore how social bots influence information diffusion in social networks with theoretical support. Specifically, combining stakeholder perspective and emotional contagion theory, we proposed several questions and hypotheses to investigate the influence of social bots. Then, the study obtained 144,314 pieces of public opinion data related to COVID-19 in J city from March 1, 2022, to April 18, 2022, on Weibo, and selected 185,782 pieces of data related to the outbreak of COVID-19 in X city from December 9, 2021, to January 10, 2022, as supplement and verification. A comparative analysis of different data sets revealed the following findings. Firstly, through the STM topic model, it is found that some topics posted by social bots are significantly different from those posted by humans, and social bots play an important role in certain topics. Secondly, based on regression analysis, the study found that social bots tend to transmit information with negative sentiments more than positive sentiments. Thirdly, the study verifies the specific distribution of social bots in sentimental transmission through network analysis and finds that social bots are weaker than human users in the ability to spread negative sentiments. Finally, the Granger causality test is used to confirm that the sentiments of humans and bots can predict each other in time series. The results provide practical suggestions for emergency management under sudden public opinion and provide a useful reference for the identification and analysis of social bots, which is conducive to the maintenance of network security and the stability of social order. © 2022
ABSTRACT
This study analyzes whether government bonds can act as safe havens in the context of COVID-19. Using a panel fixed effect model, data were collected for both advanced and emerging market economies from March 11, 2020, to June 30, 2021. Robustness tests were used to add to the credibility of the findings. Our evidence supports that government bonds maintained their safe haven status during the COVID-19 pandemic. Hence, investors can still use government bonds to hedge financial market risks in the uncertain environment associated with this pandemic. Additionally, the negative effects of the COVID-19 pandemic on government bond yields in emerging economies are larger than in advanced economies. Therefore, policymakers' measures should focus on reducing COVID-19 cases to alleviate panic and diminish economic fluctuations, especially for emerging economies. Regulators can also use short-term interest rates to guide market capital flow to avoid a liquidity crisis, reducing financial stress and market uncertainty. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
ABSTRACT
Polymerase chain reaction (PCR) amplifies specific fragment of DNA molecules and has been extensively applied in fields of pathogens and gene mutation detection, food safety and clinical diagnosis which on the other hand, holds the drawbacks of large size instrument, high heat dissipation etc. It has been demonstrated that microfluidics technique coupling with PCR reaction exhibits characteristics of integration, automatization, miniaturization, and portability. Meanwhile, various designed fabrication of microchip could contribute to diverse applications. In this review, we summarized major works about a variety of microfluidic chips equipped with several kinds of PCR techniques (PCR, RT-PCR, mPCR, dPCR) and detection methods like fluorescence, electrochemistry, and electrophoresis detection. The development and application of PCR-based microfluidic chip in pathogen and gene mutation detection, diseases prevention and diagnosis, DNA hybridization and low-volume sample treatment were also discussed. Copyright © 2022 Elsevier B.V.
ABSTRACT
OBJECTIVE: Transplant recipients have a higher risk of SARS-CoV-2 infection owing to the use of immunosuppressive drugs like tacrolimus (FK506). FK506 and nirmatrelvir (NMV) (an anti-SARS-CoV-2 drug) are metabolized by cytochrome P450 3A4 and may have potential drug-drug interactions. It is important to determine the effect of NMV on FK506 concentrations. PATIENTS AND METHODS: Following protein precipitation from blood, FK506 and its internal standard (FK506-13C,2d4) were detected by ultra-high performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS). Total 22 blood samples (valley concentrations) from two coronavirus disease 2019 (COVID-19) patients were collected and analyzed for FK506 concentrations. RESULTS: Blood levels of FK506 (0.5-100 ng/mL) showed good linearity. The UHPLC-MS/MS method was validated with intra- and inter-batch accuracies of 104.55-107.85%, and 99.52-108.01%, respectively, and precisions of < 15%. Mean blood FK506 concentration was 12.01 ng/mL (range, 3.15-33.1 ng/mL). Five-day co-administration with NMV increased the FK506 concentrations from 3.15 ng/mL to 33.1 ng/mL, returning to 3.36 ng/mL after a 9-day-washout. CONCLUSIONS: We developed a simple quantification method for therapeutic drug monitoring of FK506 in patients with COVID-19 using UHPLC-MS/MS with protein precipitation. We found that NMV increased FK506 blood concentration 10-fold. Therefore, it is necessary to re-consider co-administration of FK506 with NMV.
Subject(s)
COVID-19 , Tacrolimus , Humans , Chromatography, High Pressure Liquid/methods , Tandem Mass Spectrometry/methods , SARS-CoV-2 , Lactams , Leucine , Reproducibility of Results , Drug MonitoringABSTRACT
The spread of COVID-19 has greatly threatened human health and economic growth. Angiotensin-converting enzyme 2 (ACE2) is a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). By attaching to ACE2, SARS-COV-2 reduces its expression and induces lung injury. Vitamin D can inhibit the progression of COVID-19 by inhibiting the activity of ROCK pathway, up-regulating ACE2 expression and bio-availability, and slowing down the adverse reactions caused by Ang II accumulation. This study explored a novel mechanism, i.e., vitamin D protects against COVID-19-induced injury by upregulating ACE2 expression. It provides theoretical guidance for the role of Vitamin D in the prevention and treatment of COVID-19. Copyright © 2022 Chinese Journal of Clinical Pharmacology and Therapeutics. All rights reserved.
ABSTRACT
In recent years, the epidemic model with anomalous diffusion has gained popularity in the literature. However, when introducing anomalous diffusion into epidemic models, they frequently lack physical explanation, in contrast to the traditional reaction-diffusion epidemic models. The point of this paper is to guarantee that anomalous diffusion systems on infectious disease spreading remain physically reasonable. Specifically, based on the continuous-time random walk (CTRW), starting from two stochastic processes of the waiting time and the step length, time-fractional space-fractional diffusion, time-fractional reaction-diffusion and fractional-order diffusion can all be naturally introduced into the SIR (S: susceptible, I: infectious and R: recovered) epidemic models, respectively. The three models mentioned above can also be applied to create SIR epidemic models with generalized distributed time delays. Distributed time delay systems can also be reduced to existing models, such as the standard SIR model, the fractional infectivity model and others, within the proper bounds. Meanwhile, as an application of the above stochastic modeling method, the physical meaning of anomalous diffusion is also considered by taking the SEIR (E: exposed) epidemic model as an example. Similar methods can be used to build other types of epidemic models, including SIVRS (V: vaccine), SIQRS (Q: quarantined) and others. Finally, this paper describes the transmission of infectious disease in space using the real data of COVID-19.
ABSTRACT
Introduction: Ofatumumab (OMB), a fully-human anti-CD20 monoclonal antibody (Ab), is indicated for the treatment of adults with relapsing multiple sclerosis (RMS). As OMB induces B-cell depletion, it is important to understand if OMB-treated patients (pts) can mount a protective immune response to the COVID-19 vaccine. Objective(s): Assess humoral immune response (HIR) to mRNA COVID-19 vaccines in OMB-treated pts with RMS. Method(s): This was an open-label, single-arm, multicentre, prospective pilot study (NCT04847596) of pts with RMS aged 18-55y receiving 2 doses of an mRNA COVID-19 vaccine after treatment with OMB 20mg for >=1mo. Pts who received a 3rd/ booster vaccine dose were also eligible. Exclusion criteria included prior COVID-19 diagnosis, recent major infections and prior sphingosine 1-phosphate receptor modulator or natalizumab treatment. The 1st post-vaccination immune assay was performed >=14d after full vaccination course (2 or 3 doses), with the 2nd assay conducted 90d after the 1st assessment (assays conducted by local laboratories). Primary endpoint was proportion of pts achieving an HIR, defined as a positive response on the SARS-CoV-2 qualitative IgG Ab assay. Secondary endpoints were adverse events (AEs) and serious AEs. Result(s): 26 pts (median [range] age: 42 [27-54]y) were included;81% were female, 96% were White and 35% were Hispanic/Latino. Median (range) OMB treatment duration at screening was 237d (50-364). 15 pts (58%) received 2 vaccine doses;11 (42%) received a 3rd/booster dose. HIR to COVID-19 vaccines was achieved by 14/26 pts (54% [95%CI: 33%-73%]) at the 1st post-vaccination assay. In pts who received a booster;7/10 achieved an HIR and 6/7 aged <50y achieved HIR. Prior ocrelizumab use or age >=50y led to a decreased HIR while length of OMB treatment and COVID-19 mRNA vaccine type did not impact HIR. At the 2nd assay, 13/26 pts (50% [95%CI: 30%-70%]) achieved an HIR (10 pts maintained and 3 additional pts achieved HIR;2 pts who achieved HIR at the 1st assay were negative at the 2nd assay;2 pts had missing assays). Overall, 5/26 pts (19%) reported >=1 AEs, including COVID-19 infection (n=4), herpes zoster infection (n=1), S. pharyngitis (n=1) and headache (n=1). No serious AEs were reported. Conclusion(s): These findings suggest that most OMB-treated pts with RMS mount an HIR after COVID-19 mRNA vaccination and may help inform the coordination of vaccination and treatment of RMS pts with OMB.
ABSTRACT
Social distancing strategy (including Six-Foot Rule, wearing masks, and other easy-to-operate measures) and quarantine measures have played a critical role in the early stage of the COVID-19 epidemic. In order to explore the mechanisms of these two human interventions accurately, we develop a coupling epidemiological-behavioral model based on evolutionary game the-ory. Individuals decide whether to take strategy measures based on rational consideration of payoffs. Moreover, authorities also balance the costs and effectiveness of the interventions at the public level. Our simulation shows that social distancing strategy can suppress every single outbreak effectively. In the early stage of an epidemic, the implementation of the quarantine measures determines the scale of the epidemic. Timely and effective quarantine measures can control recurrent outbreaks without social lockdown. Support policy for individual-level intervention or high diagnosis rates are beneficial to control the epidemic but require long-term social lockdown. © 2022, Wilmington Scientific Publisher. All rights reserved.